Which vitamin-infused hand creams offer the best hydration and nourishment for dry, cracked hands?
We’ve tested 10 top formulas enriched with vitamins C, E, and B5 to help you find the perfect daily moisturizer for soft, healthy skin.
Dry, cracked hands can be a real bother, but the right hand cream can make all the difference. Vitamin-infused hand creams are a game-changer, offering deep hydration and nourishment for your skin. These creams are packed with essential vitamins like C, E, and B5, which help repair and protect your hands.
Vitamins work wonders for your skin. They soothe, hydrate, and brighten, leaving your hands feeling soft and smooth. With natural ingredients and fast-absorbing formulas, these creams are perfect for daily use.
We’ve tested and reviewed the best vitamin-infused hand creams to help you find the perfect match. From lightweight options to rich, nourishing treatments, we’ve got you covered. Get ready to say goodbye to dry hands and hello to soft, healthy skin.
List of Top 10 Vitamin-Infused Hand Creams
| Image | Title | Best For | Price |
|---|---|---|---|
 |
Advanced Clinicals Vitamin C Body & Hand Lotion Moisturizing Skin Care Cream For Hands & Body – Intense Soothing & Hydrating Vitamin C Hand Cream Moisturizer For Dry Cracked Hands, Large 8 Fl Oz |
This Vitamin C Hand Lotion is perfect for anyone with dry, chapped hands. It’s great for daily use, all skin types, and anyone wanting soft, smooth hands. |
|
 |
Mario Badescu Rose Hand Cream with Vitamin E for Men and Women, Non-Greasy, Light and Fast-Absorbing Hand Cream for Dry Cracked Hands, Ideal for All Skin Types, 3 Oz |
This hand cream is perfect for anyone with dry, cracked hands. It’s light, fast-absorbing, and non-greasy, making it ideal for daily use. |
|
 |
Derma E Vitamin E Fragrance Free Sensitive Skin Shea Hand Repair Cream – Intensive Therapy Hand Cream – Cruelty Free Unscented Lotion for Dry or Cracked Skin, 2 oz |
This hand cream is perfect for anyone with dry, cracked, or sensitive skin. It’s fragrance-free, cruelty-free, and packed with natural ingredients to soothe and hydrate your hands. |
|
 |
Gold Bond Citrus Pop Glowing Hand Cream, Everyday Hand Cream with Vitamin C to Help Visibly Brighten & Green Tea to Help Protect Skin from Environmental Stressors, Vibrant Citrus Pop Scent, 3 oz, 4 pk |
This hand cream is perfect for anyone who wants soft, glowing hands. It’s great for daily use, smells fresh, and protects your skin. |
|
 |
No7 Protect & Perfect Intense Advanced Nourishing Hand and Nail Cream – Anti Aging Hand Cream with Vitamin B5 – Contains Matrixyl 3000+ Collagen Peptide Anti Wrinkle Technology (75 ml) |
This hand cream is perfect for women who want visible results without the fuss. If your hands feel dry, look lined, or need serious nourishment, this formula delivers fast hydration and fights aging signs. Mature skin, busy routines, and daily wear deserve this level of care—it’s simple, effective, and built for real life. Try it and see smoother, younger-looking hands in just two weeks. |
|
 |
EFFIEBETY 6 Pack Vitamin B5 Hand Cream, Fast-Absorbing & Non-Greasy for Deeply Hydrated, Soft Skin, Infused with Hibiscus Flower, Rose & Peony, Vegan & Cruelty-Free (1 fl oz) |
This hand cream is perfect for anyone with dry hands who wants soft, smooth skin. It’s great for daily use, even in dry environments or after frequent hand-washing. |
|
 |
Dermal Defense Hand Cream |
Dermal Defense Hand Cream is perfect for anyone who wants soft, smooth hands. It’s great for daily use, nourishes deeply, and keeps hands comfy all day. |
|
 |
ÉCLAT NATUREL Shea Butter Hand Cream, with Vitamin E and 45% Shea Butter Hand Moisturizer, Deep Moisturizing Cream for Dry Hands, Mini Travel Size Hand Lotion Set, 1 Fl Oz (Pack of 2) |
Dry, cracked hands? Sensitive skin? Frequent hand-washers? This hand cream is perfect for you. Packed with 45% shea butter and vitamin E, it delivers deep, lasting moisture without greasiness. Gentle enough for daily use, even on sensitive or overworked skin, it soothes, protects, and leaves hands soft and resilient. If you want serious hydration from clean, natural ingredients, this is your must-have. |
|
 |
Mario Badescu Lavender Hand Cream with Vitamin E for Dry Cracked Hands, Lightweight, Fast-Absorbing Moisturizing Lotion for Dry Skin, Soothing, Non-Greasy Hydration for All Skin Types |
This hand cream is perfect for anyone with dry, cracked hands who wants fast, non-greasy relief. It’s great for all skin types and daily use. |
|
 |
Vaseline Intensive Care Hand Crème Moisturizer for Dry Hands Hydra Replenish Made with hyaluronic acid, vitamin B3, and cocoa butter 3.4 oz 6 Count |
This hand crème is perfect for anyone with dry hands who wants soft, nourished skin. It’s great for daily use and works fast to lock in moisture. |
Detailed Reviews
Discover the top 10 Vitamin-Infused Hand Creams handpicked for soft, hydrated hands. Each cream is expert-reviewed and loved by users, offering comfort and value. Whether you need fast relief or long-lasting moisture, this guide has you covered. Find the perfect match for your skin and enjoy healthy, happy hands every day.
1. Advanced Clinicals Vitamin C Body & Hand Lotion Moisturizing Skin Care Cream For Hands & Body – Intense Soothing & Hydrating Vitamin C Hand Cream Moisturizer For Dry Cracked Hands, Large 8 Fl Oz
Advanced Clinicals Vitamin C Body & Hand Lotion is a fast-acting solution for dry, cracked hands. It deeply moisturizes and soothes with natural ingredients like shea butter and sunflower oil.
This non-greasy cream has a light, fresh scent and works for all skin types. It’s affordable, effective, and made in Chicago.
| Pros | Cons |
|---|---|
|
|
Perfect For:
This Vitamin C Hand Lotion is perfect for anyone with dry, chapped hands. It’s great for daily use, all skin types, and anyone wanting soft, smooth hands.
Ready to Purchase?
2. Mario Badescu Rose Hand Cream with Vitamin E for Men and Women, Non-Greasy, Light and Fast-Absorbing Hand Cream for Dry Cracked Hands, Ideal for All Skin Types, 3 Oz
Silky hands in seconds. This fast-absorbing hand cream melts into dry skin without greasy residue. Rose-scented freshness feels light and clean all day long. Made for everyone, every day.
Hydrates deeper, longer. Packed with Vitamins A & E plus glycerin, it repairs cracks and locks in moisture for hours. Proudly cruelty-free and crafted in the USA with care.
| Pros | Cons |
|---|---|
|
|
Perfect For:
This hand cream is perfect for anyone with dry, cracked hands. It’s light, fast-absorbing, and non-greasy, making it ideal for daily use.
Ready to Purchase?
3. Derma E Vitamin E Fragrance Free Sensitive Skin Shea Hand Repair Cream – Intensive Therapy Hand Cream – Cruelty Free Unscented Lotion for Dry or Cracked Skin, 2 oz
Dry, cracked hands? Relief is here. This fragrance-free hand cream soothes sensitive skin fast. Made with gentle, natural ingredients you can trust.
Shea butter and vitamin E deliver deep, lasting moisture. Aloe and pro-vitamin B5 calm irritation and heal chapped skin. Absorbs quickly—no greasy residue, just soft comfort.
Safe for vegan and cruelty-free routines. Free from parabens, sulfates, and harsh chemicals. Recyclable packaging helps you care for skin and planet.
| Pros | Cons |
|---|---|
|
|
Perfect For:
This hand cream is perfect for anyone with dry, cracked, or sensitive skin. It’s fragrance-free, cruelty-free, and packed with natural ingredients to soothe and hydrate your hands.
Ready to Purchase?
4. Gold Bond Citrus Pop Glowing Hand Cream, Everyday Hand Cream with Vitamin C to Help Visibly Brighten & Green Tea to Help Protect Skin from Environmental Stressors, Vibrant Citrus Pop Scent, 3 oz, 4 pk
Gold Bond Citrus Pop Glowing Hand Cream comes in a 4-pack, so you always have it at home or on the go. Each bottle is 3 oz, perfect for travel, gifting, or daily use.
This hydrating formula keeps skin moisturized for 24 hours. It’s made with vitamin C to brighten skin and green tea to protect from environmental stress.
The silky, non-greasy cream absorbs quickly. It’s dermatologist-tested, cruelty-free, and free of parabens, phthalates, and dyes.
| Pros | Cons |
|---|---|
|
|
Perfect For:
This hand cream is perfect for anyone who wants soft, glowing hands. It’s great for daily use, smells fresh, and protects your skin.
Ready to Purchase?
5. No7 Protect & Perfect Intense Advanced Nourishing Hand and Nail Cream – Anti Aging Hand Cream with Vitamin B5 – Contains Matrixyl 3000+ Collagen Peptide Anti Wrinkle Technology (75 ml)
No7 Protect & Perfect Hand Cream is a rich, fast-absorbing treatment for dry hands. It works as both a hand cream and cuticle cream. This cream gives instant moisture and deep nourishment.
It has anti-aging actives like Pro-Retinol and Pro-Vitamin B5. These help reduce fine lines and wrinkles. Your hands will feel supple and look younger in just 2 weeks.
Part of the Protect & Perfect Collection, this cream is great for all skin types. It’s affordable and empowers women to feel confident. Discover more at the No7 Amazon store.
| Pros | Cons |
|---|---|
|
|
Perfect For:
This hand cream is perfect for women who want visible results without the fuss. If your hands feel dry, look lined, or need serious nourishment, this formula delivers fast hydration and fights aging signs. Mature skin, busy routines, and daily wear deserve this level of care—it’s simple, effective, and built for real life. Try it and see smoother, younger-looking hands in just two weeks.
Ready to Purchase?
6. EFFIEBETY 6 Pack Vitamin B5 Hand Cream, Fast-Absorbing & Non-Greasy for Deeply Hydrated, Soft Skin, Infused with Hibiscus Flower, Rose & Peony, Vegan & Cruelty-Free (1 fl oz)
EFFIEBETY Hand Cream gives instant hydration for dry hands. It leaves skin soft and smooth with a non-greasy feel.
This cream has hibiscus, rose, and peony. These botanicals nourish and protect your skin. The warm woody scent is inviting and soothing.
It keeps hands hydrated all day, even after washing or in dry air. The lightweight formula lets you move freely. Enjoy natural relief for dry, cracked skin.
| Pros | Cons |
|---|---|
|
|
Perfect For:
This hand cream is perfect for anyone with dry hands who wants soft, smooth skin. It’s great for daily use, even in dry environments or after frequent hand-washing.
Ready to Purchase?
7. Dermal Defense Hand Cream
Nourish instantly. This rich, vitamin-infused hand cream absorbs fast without greasy residue, leaving your skin smooth and comfortable right away.
Lock in lasting softness. Our Triple Airless Protection System shields every pump of pure formula, preserving freshness, potency, and hygiene from first use to last.
Gentle enough for daily care. Made in the USA and free of fragrance, it soothes and brightens sensitive hands safely, every single day.
| Pros | Cons |
|---|---|
|
|
Perfect For:
Dermal Defense Hand Cream is perfect for anyone who wants soft, smooth hands. It’s great for daily use, nourishes deeply, and keeps hands comfy all day.
Ready to Purchase?
8. ÉCLAT NATUREL Shea Butter Hand Cream, with Vitamin E and 45% Shea Butter Hand Moisturizer, Deep Moisturizing Cream for Dry Hands, Mini Travel Size Hand Lotion Set, 1 Fl Oz (Pack of 2)
ÉCLAT NATUREL Shea Butter Hand Cream is a deeply moisturizing treat for dry hands. With 45% shea butter, it provides long-lasting hydration and softens your skin. This mini travel size set is perfect for on-the-go use.
The natural ingredients in this hand cream are gentle and safe for daily use. It’s paraben-free, phthalate-free, and dye-free, making it suitable for sensitive skin. The light scent is a pleasant bonus, uplifting your spirits with every application.
This hand cream is a must-have for anyone seeking soft, hydrated hands. With its high-quality, natural formula, it’s a reliable choice for daily hand care.
| Pros | Cons |
|---|---|
|
|
Perfect For:
Dry, cracked hands? Sensitive skin? Frequent hand-washers? This hand cream is perfect for you. Packed with 45% shea butter and vitamin E, it delivers deep, lasting moisture without greasiness. Gentle enough for daily use, even on sensitive or overworked skin, it soothes, protects, and leaves hands soft and resilient. If you want serious hydration from clean, natural ingredients, this is your must-have.
Ready to Purchase?
9. Mario Badescu Lavender Hand Cream with Vitamin E for Dry Cracked Hands, Lightweight, Fast-Absorbing Moisturizing Lotion for Dry Skin, Soothing, Non-Greasy Hydration for All Skin Types
Mario Badescu Lavender Hand Cream is perfect for dry, cracked hands. It’s lightweight and fast-absorbing, so hands feel soft, not greasy.
This cream has Vitamin E and lavender to nourish and calm skin. It’s gentle for all skin types and works fast.
Use it daily for soothing hydration. The lavender scent adds a relaxing touch to your routine.
| Pros | Cons |
|---|---|
|
|
Perfect For:
This hand cream is perfect for anyone with dry, cracked hands who wants fast, non-greasy relief. It’s great for all skin types and daily use.
Ready to Purchase?
10. Vaseline Intensive Care Hand Crème Moisturizer for Dry Hands Hydra Replenish Made with hyaluronic acid, vitamin B3, and cocoa butter 3.4 oz 6 Count
Vaseline Intensive Care Hand Crème is a 2022 Allure Best of Beauty Winner. It’s made with hyaluronic acid, vitamin B3, and cocoa butter. These ingredients work together to hydrate and nourish your hands.
This hand crème is perfect for dry hands. It locks in moisture for long-lasting softness. After just one use, your skin feels soft and smooth.
Use it daily for relief. The non-greasy formula melts into your skin. Your hands look and feel visibly nourished.
| Pros | Cons |
|---|---|
|
|
Perfect For:
This hand crème is perfect for anyone with dry hands who wants soft, nourished skin. It’s great for daily use and works fast to lock in moisture.
Ready to Purchase?
Buying Guide
Dry, cracked hands need the right care. Vitamin-infused hand creams are a great choice. They hydrate, nourish, and protect your skin.
Choosing the best hand cream can feel overwhelming, but we’re here to help. We’ve tested top products to find the perfect match for you. Say goodbye to dryness and hello to soft, healthy hands.
Here’s what to consider when buying:
- Vitamins: Look for vitamins C, E, and B5. They repair, soothe, and brighten your skin.
- Ingredients: Choose natural ingredients like shea butter, aloe, and sunflower oil. They’re gentle and effective.
- Absorption: Go for fast-absorbing formulas. They leave no greasy residue and feel light on your skin.
- Scent: Pick a light, fresh scent or fragrance-free options if you have sensitive skin.
- Skin Type: Ensure the cream works for all skin types or matches your specific needs, like sensitive or dry skin.
- Packaging: Consider travel-friendly sizes or recyclable packaging for eco-friendly choices.
- Price: Look for affordable options that don’t compromise on quality.
- Cruelty-Free: Choose cruelty-free and vegan products if that’s important to you.
With these tips, you’ll find the perfect vitamin-infused hand cream for your needs. Enjoy soft, nourished hands every day!